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Autoimmune Diseases Awareness

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Autoimmune diseases arise from an inappropriate immune response of the body against substances and tissues normally present in the body. In other words, the immune system mistakes some part of the body as a pathogen and attacks its own cells.

Autoimmune diseases can be very deadly, especially when you are unaware.

Get daily updates and information about Autoimmune diseases to protect yourself or your family about its horrible side effects.

GENES HAS SOMETHING TO DO WITH AUTOIMMUNE DISEASES

As soon as a body comes across somewhat unfamiliar in its surroundings it needs to be able to accumulate an immune response against that substance in order to protect itself from probable harm. In doing this effectively, it must be able to be familiar with what is self in order to act in response to non-self or foreign. With autoimmune diseases, there is a failure to recognize some part of self. Such autoimmunity may be constrained to a single organ, a localized region or the whole animal. The consequences may vary from minimal to terrible, depending on the extent to which the body is affected. Pathologic signs are seen in autoimmune disease as a result of the autoimmune response. Regularly more than one autoimmune disease will be seen in the same animal, as well as an increased susceptibility to bacterial infection.

A particular major histocompatibility complex (MHC) genes as can be shown in humans are related with the incidence of specific autoimmune diseases. All vertebrates have MHC genes and are strange in that they are inherited as a unit. They encode for two major categories of molecules that form part of cell membranes and cross the entire membrane. Particularly, they have a role in selecting the antigens known by T-cells.

An analysis of the pedigrees received of beardies affected by hypoadrenocorticism, suggests that this disease is caused by an autosomal recessive gene with incomplete penetrance. It is being hoped for to identify a gene or genes at one or more loci which associate with hypoadrenocorticism. To date blood samples and pedigrees were received from well over 100 beardies which are either affected with the disease or closely related to affected dogs. The same goes with other breed clubs being involved in the project. Without a doubt, a blood test for the disease would enable us to reduce the incidence radically.

Study of pedigrees from a tremendously large population of Old English sheepdogs and smaller populations of other breeds, has shown that almost all cases of autoimmune disease occur in particular blood lines. Vaccinosis reactions occur in the same blood lines. Nevertheless, it is likewise clear that not all dogs within these groups will develop an autoimmune disease. Rather, majority of it will live normal, healthy lives, although some may have sub-clinical autoimmune disorders.

Therefore, it is concluded that it seems possible that a dog must have a genetic tendency in order to develop an autoimmune disease. On the other hand, for evident disease to manifest itself specific insults to the animal’s immune system must also be presented.

Moreover, some of the factors which can influence whether a dog will develop an autoimmune disease are being gathered together. The health of its immune system in general seems to be a major factor. Dogs are at far more risk when they are already stressed by disease. Hence, it is very important that we do not further stress a sick dog by vaccinating it. Reported incidence of autoimmune disease is increasing, and there is some deliberation as to whether this is because it is really more common or because we are keen at detecting it. It is to believe that both factors are probably involved.

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